Talk: Body-on-a-Chip – The New Frontier in Drug Discovery – Wed, 02/20/19 @UCI

Body on a Chip.jpg

Wednesday, February 20, 2019 • 4:00 PM
Crystal Cove Auditorium, UC Irvine Student Center
Reception to follow the lecture at 5:00 PM

Chris Hughes

Featuring Christopher C.W. Hughes, Ph.D.
Chair and Professor
Molecular Biology and Biochemistry

About the Lecture
Identifying effective new medicines is time-consuming and expensive. Ideally, drugs are highly specific, having great efficacy and minimal toxicity, however this is rarely the case. Current drug pipelines follow very similar trajectories: simple cell-based assays reveal promising compounds that are then tested in mice, and, if these studies are successful, lead agents progress into first-in-man studies, and finally full-scale clinical trials. Unfortunately, fewer than 1 in 7 drugs entering clinical trials make it to market. Two major problems with this pipeline can be identified: the cell-based assays are too simple, not reproducing the complexity of cells in the body; and mice are not men – mouse metabolism and drug sensitivities are often very different to our own. 

Body-on-a-Chip technology aims to solve these problems. Three-dimensional “mini-organs” can be created in the lab that better model how cells behave in the body, and human cells can be used to capture human-specific responses. Numerous studies have now shown that these systems can perform better in modeling how drugs behave in people than both traditional cell-based assays and mouse testing. Moving from the lab to the clinic, we are now taking tumors from cancer patients and growing them in these platforms. Our long-term goal is to use this technology to identify the optimal combination of drugs to treat each individual patient – truly personalized medicine. Dr. Hughes is a world leader in the field of microphysiological systems (body-on-a-chip) technology and will describe how these revolutionary models are set to change how drugs are discovered, tested and prescribed.
Reservations are requested. 
Refreshments will be served at the reception

following the lecture.

The event is open to the public and the UCI campus community.
Parking is available for $10 per vehicle at the UCI Student Center Parking Structure.

Register Here!



International Coastal Cleanup – Sat, 09/15 @9am


Volunteer this Saturday (09/15) from 9am-12pm to collect and document trash on our coastlines and in our inland parks. International Coastal Cleanup started 30 years ago and continues to this day. Beyond picking up trash, volunteers are asked to record items collected on a data card to help identify ways to minimize littering and pollution in the future. On this day, more than 100 countries will be participating.

For all of these events, you must RSVP and sign a waiver using the California Coastal Commission’s website:

Local Cleanup Events

La Habra at Coyote Creek
1641 W. Imperial Hwy – Located along Fashion Square Lane behind La Habra Marketplace.

Clark Regional Park
8800 Rosecrans Ave Buena Park, CA 90621 United States

175 S Madrona Ave, Brea, CA 92821 Bottom floor of the parking structure

People’s Climate Day of Action – Sat 09/08 @10am

Fullerton Science March

Although not an official Science Club event, we encourage you to attend the People’s Climate March this Saturday at Fullerton City Hall and have your voices heard.

“The Peoples Climate Movement uses two key strategies to demand bold action on climate change:  mass mobilization and movement alignment. By mobilizing massive numbers of people on the ground; finding alignment with partners under the banner of climate, jobs, and justice; and lifting up our core priorities of economic and racial justice, we build the power required to win real and lasting climate policy on the federal, state, and local level.”

People’s Climate Day of Action – CA39 Fullerton
September 08, 2018 • 10:00 AM
Fullerton City Hall
303 W. Commonwealth Ave Fullerton, CA 92832

RSVP for People’s Climate Day of Action in Fullerton

UCI Medical School Open House, 09/22

UCI Open House

Science Club will be taking a trip to UCI’s Open Medical School Event on September, 22 from 8:00am-12:00pm. You must RSVP on their website before September 1 (link below). We will provide transportation.

“UCI School of Medicine’s Division of Diversity & Inclusion cordially invites you to Fall 2018’s Open Medical School, an exclusive open house event for students, in Jr. High School through College, interested in the field of medicine.

Attendees will get an opportunity to learn from medical students, staff and faculty at the UC Irvine School of Medicine. Live demonstrations of ultrasound, suturing, and simulation center will also be available.

UCI is committed to engaging with aspiring physicians and helping them to achieve their goals. Open Medical School affords the chance to learn about medical training and careers, while developing relationships and mentors within our School of Medicine. We plan several events during the year in our effort to develop pipelines to medical school.

Light breakfast will be served.”

Click here to RSVP by September 1!

Last Meetings of Semester!

Tuesday, May 08 3pm-4pm Election in Room 412

Nominees will have an opportunity to speak to the club and then club members will vote to select the new board members for the Fall 2018-Spring 2019 academic year.

Then… a very special meeting afterwards. Dr. Nolan-Riegle will give her famous “Chocolate Talk” and we will celebrate the end of the semester with a potluck. This will take place at 4:45pm-5:45pm in Room 441. RSVP here! Everyone is welcome!

SC Potluck and Choc Talk Flier SP18

Science Club Meeting (Tues 04/10/18)

Our next meeting will be tomorrow, Tuesday 4/10 at 3pm in Room 436NOTE: We are meeting in a different room this time because we will be making soap from scratch! It will be a lot of fun and I hope you all can attend.
Also, there will be an event aimed at supporting the Newport Bay Conservancy which Science Club sadly will not be attending, however, we still would like to help out. The Newport Bay Conservancy is a local nonprofit that works to conserve, restore, and protect the Upper Newport Bay. They have a wishlist of donation items to help them with their cause so if you can donate any of the following items, please bring them to the meeting tommorow.
– shovels
– gardening gloves
– rubber gloves
– heavy duty trash bags
– first aid kits
– sun block
NBC wishlist